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50646
5-Azacytidine
Activators & Inhibitors
Chemical Modulators

5-Azacytidine #50646

Citations (0)
Chemical structure of 5-Azacytidine.

Product Usage Information

5-Azacytidine is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.37 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Wear personal protective equipment. Do not empty product into drains. Do not handle until all safety precautions have been read and understood.

Safety Information: 5-Azacytidine has been classified by the International Agency for Research on Cancer (IARC) as a probable human carcinogen (Group 2A). It is suspected of causing genetic defects. It may cause adverse reproductive effects - such as birth defect, miscarriages, or infertility. Avoid contact during pregnancy and while nursing. If exposed or concerned, get medical advice. See Safety Data Sheet (SDS).

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Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 244.2 g/mol
Purity >98%
Molecular Formula C8H12N4O5
CAS 320-67-2
Solubility Soluble in DMSO at 25 mg/mL or water at 12 mg/mL.

Background

5-Azacytidine is a nucleoside analogue of cytidine and a DNA methyltransferase inhibitor. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases, which contributes to reversing DNA methylation (1). It also functions in reducing DNA hypermethylation in certain diseases, including myelodysplastic syndrome (MDS) (2).

Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not for Use in Diagnostic Procedures.
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To Purchase # 50646
Cat. # Size Qty. Price
50646S
50 mg