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97061
Bromosporine
Activators & Inhibitors
Chemical Modulators

Bromosporine #97061

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other Image 1 - Bromosporine

Chemical structure of Bromosporine.

Product Usage Information

Bromosporine is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.23 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 404.4 g/mol

Purity: >98%

Molecular Formula: C17H20N6O4S

CAS: 1619994-69-2

Solubility: Soluble in DMSO at 25 mg/ml.

Background

Bromosporine is a potent broad-spectrum bromodomain inhibitor (1). Bromodomain and extra-terminal (BET) protein family members BRD2, BRD3, BRD4, and BRDT associate with acetylated lysines on histones and transcription factors to regulate their function, and have emerged as targets for cancer therapy (2,3). Treatment with Bromosporine induced the expression of latent HIV-1 in primary CD4+ T cells by inhibiting BET activity, leading to improved viral clearance in conjunction with antiretroviral therapy (4).

  1. Picaud, S. et al. (2016) Sci Adv 2, e1600760.
  2. Roberts, T.C. et al. (2017) Sci Rep 7, 6153.
  3. Cheng, X. et al. (2020) Biochem Biophys Res Commun 521, 840-5.
  4. Pan, H. et al. (2017) Oncotarget 8, 94104-16.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 97061S
Product # Size Price
97061S
5 mg N/A

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