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26941
Human NRG1-β1 Recombinant Protein
Cytokines
Growth Factors and Cytokines

Human NRG1-β1 Recombinant Protein #26941

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Human NRG1-β1 Recombinant Protein: Image 1
The purity of Human NRG1-β1 Recombinant Protein was determined by SDS-PAGE of 1 µg reduced (+) and non-reduced (-) recombinant hNRG1-β1 and staining with Coomassie Blue.

Storage

Human NRG1-β1 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.

Product Description

MW (kDa) 7.6
Purity A greater than or equal to 95% purity was determined by SDS-PAGE.
Endotoxin Endotoxin levels are less than or equal to 1 EU / 1 μg hNRG1-β1.

Source / Purification

Recombinant human NRG1-β1 was expressed in E. coli and is supplied in a lyophilized form.

Background

Neuregulin 1 (NRG1), a member of the EGF family, is involved in heart, mammary, and nervous system development (1). NRG1 is expressed by mammary epithelial, vascular endothelial, and neuronal cells (2,3). At least 15 NRG1 splice variants are known (1). These variants differ in EGF domains (α or β variants), amino-terminal splicing sites, and in the incorporation of exons encoding integral membrane regions (1). NRG1 can induce or inhibit the proliferation of cells derived from breast cancer. The differences in effects of NRG1 appear to depend on splice variation and interaction with receptor(s) (2). NRG1 binds to ErbB3/HER3 or ErbB4/HER4. Binding induces dimerization with ErbB2/HER2. The Akt, Erk1/2, and Erk5 pathways have been shown to participate in NRG1 activated signaling (4,5). NRG1 appears to have roles in schizophrenia and breast cancer (1,4,6).
  1. Falls, D.L. (2003) Exp Cell Res 284, 14-30.
  2. Chua, Y.L. et al. (2009) Oncogene 28, 4041-52.
  3. Kalinowski, A. et al. (2010) FASEB J 24, 2567-75.
  4. Montero, J.C. et al. (2008) Clin Cancer Res 14, 3237-41.
  5. Grossmann, K.S. et al. (2009) Proc Natl Acad Sci U S A 106, 16704-9.
  6. Mei, L. and Xiong, W.C. (2008) Nat Rev Neurosci 9, 437-52.

Pathways & Proteins

Explore pathways + proteins related to this product.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 26941
Cat. # Size Qty. Price
26941S
10 µg N/A

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