Can I store my glycerol-formulated antibody at -80C?

We have tested a representative group of rabbit polyclonal, rabbit monoclonal, and mouse monoclonal antibodies and saw no change in their activity after two freeze/thaw cycles on dry ice (-78.5C). However, because freeze/thaw cycles are known to cause damage to antibodies, we cannot offer any firm guarantees.

Most of our off-the-shelf antibodies are supplied in a 50% glycerol buffer and will not freeze when stored as recommended at -20C. Regrettably, we do not have sufficient stability data for long-term storage at other temperatures. Therefore, for ideal long-term storage, antibodies should be stored at -20C. Any potential damage from repeated freeze/thaw cycles is avoided at this temperature. 
 

Last updated: March 10, 2023