Interested in promotions? | Click here >>
Activators & Inhibitors
Chemical Modulators

17-AAG #8132

Reviews ()
Citations (0)
other Image 1 - 17-AAG

Western blot analysis of extracts from LNCaP cells, untreated (-) or treated with 17-AAG (1 μM, 24 hr), using Akt (pan) (11E7) Rabbit mAb #4685 (upper) and β-Actin (13E5) Rabbit mAb #4970 (lower).

other Image 2 - 17-AAG

Chemical structure of 17-AAG (17-Demethoxy-17-allyaminogeldanmycin)

Product Usage Information

17-AAG is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 500 μg in 853.7 μl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 0.1-1 μM for 4-24 hours. Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Maximum solubility in plain water estimated to be about 20-50 μM.


Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight:

585.70 g/mol



Molecular Formula:



17-AAG is a semi-synthetic derivative of geldanamycin, demonstrating greater stability than its parent compound (1). It binds specifically to heat shock protein HSP90 in a manner similar to geldanamycin, but with weaker binding (1). Through specific binding with HSP90, 17-AAG has been shown to decrease levels of many proteins including androgen receptor (AR), HER2, and Akt, while increasing levels of HSP90 in prostate cancer cell lines (2). 17-AAG binds to a conserved pocket in the HSP90 family of chaperone proteins and this occupation causes the degradation of several signaling proteins (2).

  1. Schulte, T.W. and Neckers, L.M. (1998) Cancer Chemother Pharmacol 42, 273-9.
  2. Solit, D.B. et al. (2002) Clin Cancer Res 8, 986-93.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 8132S
Product # Size Price
500 µg N/A

Powered by GlobalLink OneLink SoftwarePowered By OneLink