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90826
Apicidin
Activators & Inhibitors
Chemical Modulators

Apicidin #90826

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Apicidin: Image 1

Chemical structure of Apicidin.

Product Usage Information

Apicidin is supplied as a lyophilized powder. For a 2 mM stock, reconstitute 1 mg of powder in 801 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 623.8 g/mol
Purity

>98%

Molecular Formula

C34H49N5O6

CAS 183506-66-3
Solubility Soluble in DMSO at 10 mg/ml or ethanol at 1 mg/ml.

Background

Apicidin is a fungal metabolite, broad-spectrum antiprotozoal agent. This small molecule inhibits histone deacetylases (HDACs), known to moderate histone acetylation and chromatin folding during gene expression (1,2). Apicidin has been shown to irreversibly prevent the development of intracellular Apicomplexan parasites in vitro through HDAC inhibition (IC50 = 0.7 nM) (1). Research indicates that Apicidin inhibits tumor cell proliferation through gene expression changes of p21WAF1/Cip1 and gelsolin, and can cause cell cycle arrest in the G1 phase (2). Apicidin also decreases HIF-1α protein levels in human and mouse cell lines (3). HDAC2 has been recognized as a host immune response to the influenza A virus and several other viruses, making HDAC inhibitors important compounds to study in relation to viral diseases (4,5).

  1. Darkin-Rattray, S.J. et al. (1996) Proc Natl Acad Sci U S A 93, 13143-7.
  2. Han, J.W. et al. (2000) Cancer Res 60, 6068-74.
  3. Kim, S.H. et al. (2007) Oncol Rep 17, 647-51.
  4. Nagesh, P.T. et al. (2017) Front Microbiol 8, 1315.
  5. Walters, M.S. et al. (2009) J Virol 83, 11502-13.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 90826S
Product # Size Price
90826S
1 mg N/A

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