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9432
BCAT2 Antibody
Primary Antibodies
Polyclonal Antibody

BCAT2 Antibody #9432

Reviews ()
Citations (4)

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# Product Name Application Reactivity
  • WB
  • IP
  • IHC
H Mk

Supporting Data

REACTIVITY
SENSITIVITY
MW (kDa) 39
SOURCE Rabbit

Application Key:

  • W-Western
  • IP-Immunoprecipitation
  • IHC-Immunohistochemistry
  • ChIP-Chromatin Immunoprecipitation
  • IF-Immunofluorescence
  • F-Flow Cytometry
  • E-P-ELISA-Peptide

Species Cross-Reactivity Key:

  • H-Human
  • M-Mouse
  • R-Rat
  • Hm-Hamster
  • Mk-Monkey
  • Mi-Mink
  • C-Chicken
  • Dm-D. melanogaster
  • X-Xenopus
  • Z-Zebrafish
  • B-Bovine
  • Dg-Dog
  • Pg-Pig
  • Sc-S. cerevisiae
  • Ce-C. elegans
  • Hr-Horse
  • All-All Species Expected

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

BCAT2 Antibody recognizes endogenous levels of total BCAT2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human BCAT2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

BCAT1 and BCAT2 are cytosolic and mitochondrial branched chain aminotransferases, respectively (1,2). Research studies have implicated BCAT1 in distant metastasis in patients with advanced colorectal cancer (3). Disruption of BCAT2 in mice leads to higher levels of plasma branched-chain amino acids, reduced adiposity and body weight, and increased energy expenditure, suggesting its role in regulating insulin sensitivity (4).

  1. Bledsoe, R.K. et al. (1997) Biochim Biophys Acta 1339, 9-13.
  2. Suryawan, A. et al. (1998) Am J Clin Nutr 68, 72-81.
  3. Yoshikawa, R. et al. (2006) World J Gastroenterol 12, 5884-9.
  4. She, P. et al. (2007) Cell Metab 6, 181-94.

Pathways & Proteins

Explore pathways + proteins related to this product.

For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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